Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy (Adv. Funct. Mater. 45/2022)

Materials and Wireless Microfluidic Systems for Electronics Capable of Chemical Dissolution on Demand (Adv. Funct. Mater. 92015)

Nanomaterials for Positron Emission Tomography Imaging Guided Photothermal Cancer Therapy

Xiaolian Sun,* Xinglu Huang, Xuefeng Yan, Yu Wang, Jinxia Guo, Orit Jacobson, Dingbin Liu, Lawrence P. Szajek, Wenlei Zhu, ) Gang Niu, Dale O. Kiesewetter, Shouheng Sun, ) and Xiaoyuan Chen* Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland 20892, United States, Center ...

Design and development of CAR-T cells for cancer therapy

Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...

Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy

Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation. However, photostability and safety issues have been the technical hurdles for further clinica...

Biodegradable and Multifunctional Polymer Micro-Tubes for Targeting Photothermal Therapy

We describe an innovative form of polymer micro-tubes with diverse functions including biodegradation, magnetic manipulation, and photothermal effect that employs and activates photothermal therapy to target cancer cells. The micro-tube comprised soybean protein isolate, poly-l-glutamic acid, magnetite nanoparticles, plus gold nanoparticles. Through electrostatic force, these components, with o...